Imagine biting into a gooey, cheesy sandwich that combines the beloved flavors of pizza with the comforting texture of a grilled cheese. That’s exactly what you’ll get with these Pepperoni Pizza Grilled Cheese Sandwiches! This scrumptious creation is not only a delightful treat but also a quick meal option that will satisfy both kids and adults alike. Get ready to indulge in a melty masterpiece that will become a staple in your kitchen.
Why It’s Crowd-Pleasing

This Pepperoni Pizza Grilled Cheese Sandwich is the ultimate comfort food, merging two classic favorites into one irresistible dish. It’s perfect for a quick lunch, a satisfying dinner, or even a fun party appetizer. The combination of crispy, golden bread, rich mozzarella cheese, and savory pepperoni creates a flavor explosion that everyone will love. Plus, it’s a great way to use up leftover pizza toppings or simply spice up your regular grilled cheese routine.
What We’re Using
To create these delicious sandwiches, you’ll need a handful of simple yet flavorful ingredients:
- 2 slices of Dave’s Killer 21 Power Seed Bread – This bread is packed with nutrients and offers a hearty texture.
- 2 tablespoons mayonnaise – Adds creaminess and helps achieve that golden crust.
- 1 tablespoon butter – For that rich flavor and perfect browning.
- 2 slices mozzarella cheese – Melts beautifully to create a gooey center.
- 2 tablespoons pizza sauce – The star ingredient that brings the pizza flavor.
- 6 pepperoni slices – Classic pepperoni for that iconic taste.
Gear Up: What to Grab
Before you start cooking, make sure you have the following kitchen tools on hand:
- Skillet or frying pan – For cooking the sandwiches to perfection.
- Spatula – To flip the sandwiches without losing any fillings.
- Measuring spoons – For accurate ingredient measurements.
- Knife – To slice the sandwiches once they’re done.
Pepperoni Pizza Grilled Cheese Sandwiches, Made Easy

Ready to create your own Pepperoni Pizza Grilled Cheese Sandwiches? Follow these simple steps:
Step 1: Prepare the Bread
Start by spreading 1 tablespoon of mayonnaise on one side of each slice of Dave’s Killer 21 Power Seed Bread. This will give your sandwich a deliciously crispy crust.
Step 2: Assemble the Sandwich
On the unspread side of one slice, layer 2 slices of mozzarella cheese, then add 6 pepperoni slices on top, and drizzle with 2 tablespoons of pizza sauce. Top with the second slice of bread, mayonnaise side up.
Step 3: Heat the Pan
Place a skillet over medium heat and add 1 tablespoon of butter. Allow it to melt completely and coat the bottom of the pan.
Step 4: Cook the Sandwich
Carefully place the assembled sandwich in the pan. Cook for about 3-4 minutes or until the bread is golden brown. Use your spatula to press it down slightly for even cooking.
Step 5: Flip and Finish
Once the first side is perfectly golden, carefully flip the sandwich using the spatula. Cook the other side for another 3-4 minutes until the cheese is melted and the bread is crispy.
Step 6: Slice and Serve
Remove the sandwich from the pan, let it cool for a minute, then slice it in half. Serve with extra pizza sauce on the side for dipping!
Variations for Dietary Needs

This recipe is versatile and can be adapted to suit various dietary preferences:
- Vegetarian: Skip the pepperoni and load up on veggies like bell peppers, mushrooms, or spinach.
- Gluten-Free: Use gluten-free bread to make this sandwich suitable for gluten-intolerant diets.
- Vegan: Substitute mozzarella with a plant-based cheese and use vegan mayo and butter.
- Spicy: Add jalapeños or spicy Italian sausage for an extra kick!
Notes on Ingredients
The choice of bread is crucial for the texture and flavor of your Pepperoni Pizza Grilled Cheese Sandwiches. Dave’s Killer 21 Power Seed Bread not only offers a nutty richness but also enhances the nutritional profile of this dish. If you prefer a different flavor, feel free to experiment with your favorite bread types, including sourdough or whole grain.
When selecting your pizza sauce, opt for one that is rich and flavorful, as this will be the key to bringing out the pizza taste in your sandwich. You can even make your own homemade sauce for an extra personal touch!
Keep It Fresh: Storage Guide
If you happen to have any leftovers (though we doubt that!), here’s how to store them:
- Refrigerator: Store the sandwich in an airtight container for up to 2 days. Reheat in a skillet for the best texture.
- Freezer: Assemble the sandwich without cooking, wrap it tightly in plastic wrap, and freeze for up to 1 month. Cook directly from frozen, allowing extra time on the stove.
Your Questions, Answered
Can I use other types of cheese?
Absolutely! While mozzarella is a classic choice, feel free to experiment with provolone, cheddar, or a blend of cheeses for different flavors.
How do I make it extra crispy?
For an extra crispy sandwich, consider using a combination of butter and olive oil in the skillet. This will enhance the browning and add flavor.
Can I add more toppings?
Yes! Feel free to add toppings like olives, cooked sausage, or fresh basil to customize your Pepperoni Pizza Grilled Cheese Sandwich to your liking.
What should I serve with this sandwich?
This sandwich pairs beautifully with a side of salad or you can dip it in a warm bowl of Creamy Parmesan Tomato Tortellini With Spinach. For a heartier option, try it alongside Cheesy Buffalo Chicken Pasta Bake With Ranch Drizzle.
Next Steps
Now that you have the complete guide to making Pepperoni Pizza Grilled Cheese Sandwiches, it’s time to get cooking! Gather your ingredients, invite a friend or family member to join in on the fun, and enjoy this delightful twist on a classic dish. Don’t forget to take a picture of your creation and share it with your friends; they’ll be begging for the recipe! Happy cooking!

Pepperoni Pizza Grilled Cheese Sandwiches
Ingredients
Equipment
Method
- Spread 1 tablespoon of mayonnaise on one side of each slice of Dave's Killer 21 Power Seed Bread.
- On the unspread side of one slice, layer 2 slices of mozzarella cheese, then add 6 pepperoni slices on top, and drizzle with 2 tablespoons of pizza sauce. Top with the second slice of bread, mayonnaise side up.
- Place a skillet over medium heat and add 1 tablespoon of butter. Allow it to melt completely and coat the bottom of the pan.
- Carefully place the assembled sandwich in the pan. Cook for about 3-4 minutes or until the bread is golden brown.
- Once the first side is perfectly golden, carefully flip the sandwich using the spatula. Cook the other side for another 3-4 minutes until the cheese is melted and the bread is crispy.
- Remove the sandwich from the pan, let it cool for a minute, then slice it in half. Serve with extra pizza sauce on the side for dipping!
Notes
- For a crispy sandwich, consider using a mix of butter and olive oil.
- Experiment with different types of cheese for unique flavors.
- Try adding veggies or spices to customize your sandwich.
